Estradiol and norethindrone (topical patches) medical facts from Drugs. Generic Name: estradiol and norethindrone (topical patches) (ess tra DYE all and nor ETH in drone)Brand Name: Combipatch. What are estradiol and norethindrone? Estradiol is a form of estrogen. Estrogen is a female sex hormone that is involved in the development and maintenance of the female reproductive system. The estrogen patch (oestrogen patch) is a delivery system for estradiol, which is used as hormone replacement therapy to treat the problems of menopause, such as hot flashes and vaginal dryness, or to prevent osteoporosis. Drug information on Alora, Climara, Estraderm, Estradiol Patch, Menostar, Vivelle, Vivelle-Dot (estradiol transdermal), includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and. Medscape - Hypoestrogenism, osteoporosis, breast cancer-specific dosing for Estrace, Vivelle-Dot (estradiol), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and. Estradiol is a form of estrogen, a female sex hormone that's produced by the ovaries. Estradiol comes in an oral form, a transdermal skin patch, a vaginal ring, or as a topical gel, spray, or emulsion. The drug is available. Converting Between Estrogen Products. Topical/Transdermal Estradiol Patches (Doses indicate patch release rate of estrogen. Transdermal/topical estradiol might be. Estradiol transdermal system (twice-weekly) is an estrogen indicated for: Draft Guidance on Estradiol. Estradiol, using both baseline corrected and uncorrected data. Within 72 hours prior to dosing, use of antihistamines or use of topical drugs at patch site.Norethindrone is a form of progesterone. Progesterone is a female hormone important for the regulation of ovulation and menstruation. Together, estradiol and norethindrone are used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating (. Using a progestin, such as norethindrone, with estradiol lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away. Treatment with estrogens long- term may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before using estradiol and norethindrone long- term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3- 6 months) about whether you should continue this treatment. Have yearly physical exams and examine your breasts for lumps on a monthly basis while using estradiol and norethindrone. Do not use this medication if you are pregnant. Do not place the transdermal patch on your breasts or at your waistline where tight- fitting clothing may interfere with its functioning. What should I discuss with my healthcare provider before using estradiol and norethindrone? Do not use estradiol and norethindrone without first talking to your doctor if you havea circulation, bleeding, or blood- clotting disorder; undiagnosed, abnormal vaginal bleeding; orany type of breast, uterine, or hormone- dependent cancer. This means that estradiol and norethindrone will cause birth defects in an unborn baby. Do not use estradiol and norethindrone if you are pregnant or could become pregnant during treatment. Estradiol and norethindrone may decrease milk flow and have other effects on milk composition. Do not use estradiol and norethindrone without first talking to your doctor if you are breast- feeding a baby. How should I use estradiol and norethindrone? Use estradiol and norethindrone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. To use estradiol and norethindrone patches: Apply each patch to a smooth (fold free), clean, dry area on your lower abdomen. The area should not be oily, damaged, or irritated. Do not use the patch on your breasts or at your waistline, where clothing may interfere with its use. After opening a pouch, remove one side of the protective liner, taking care not to touch the adhesive part with your fingers. Immediately apply the patch. Remove the second side of the protective liner and press the patch firmly in place with your hand for at least 1. Replace the patch on the same two days each week (every 3 to 4 days) as directed by your doctor. Only one patch should be worn at any time. Allow at least 1 week to pass between applications of the patch to a given area. Do not cut the patches. After a patch is in place, it should not be exposed the sun for prolonged periods of time. Take care so the patch does not come off during bathing or other activities. If a patch falls off for any reason, reapply it to another site on your lower abdomen. If it will not stick, apply a new patch to a new site. Continue changing the patch on your regular schedule. Removal of the patch should be done carefully and slowly to avoid irritation of the skin. If any adhesive remains on the skin, allow it to dry for 1. Then gently rub the area with an oil- based cream or lotion. Your doctor may prescribe two different patches for you. In this treatment regimen, use the estrogen- only patch for the first 1. Then, use the estradiol and norethindrone patches for the remaining 1. Follow your doctor's instructions or ask your pharmacist for help if you do not remember. Monthly withdrawal bleeding often occurs with this regimen. Have yearly physical exams and examine your breasts for lumps on a monthly basis while using estradiol and norethindrone. Store the patches in their sealed foil pouches at room temperature away from moisture, heat, and direct light for up to 6 months from the date you receive them from the pharmacy or the expiration date, whichever comes first. What happens if I miss a dose? Apply the next patch as soon as you remember. Continue to follow your regular schedule for changing the patch. Do not use two patches simultaneously unless your doctor directs otherwise. If a patch falls off for any reason, reapply it to another site on your lower abdomen. If it will not stick, apply a new patch to a new site. Continue changing the patch on your regular schedule. What happens if I overdose? An overdose of estradiol and norethindrone is unlikely to occur and is not likely to threaten life. If you do suspect an overdose, or if a patch has been ingested, call an emergency room or poison control center for advice. Symptoms of a estradiol and norethindrone overdose may include nausea, vomiting, and withdrawal bleeding may occur in females. What should I avoid while using estradiol and norethindrone? After a patch is in place, it should not be exposed the sun for prolonged periods of time. There are no restrictions on food, beverages, or activity while using estradiol and norethindrone unless your doctor directs otherwise. Estradiol and norethindrone side effects. Treatment with estrogens long- term may increase the risk of heart attack, stroke, breast cancer, and blood clots in the lungs or legs. Because of these risks, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before using estradiol and norethindrone long- term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3- 6 months) about whether you should continue this treatment. If you experience any of the following serious side effects, stop using estradiol and norethindrone and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); sharp chest pain, coughing of blood or shortness of breath (possible blood clot in the lung ); pain in the calf (possible blood clot in the leg); crushing chest pain or heaviness in the chest (possible heart attack); sudden severe headache or vomiting, dizziness or fainting, disturbances of vision or speech, weakness, or numbness in an arm or leg (possible stroke); partial or complete loss of vision (possible clot in the eye); stomach pain or tenderness, yellowing of the skin or eyes, fever, fatigue, loss of appetite, dark- colored urine, or light- colored stools (possible liver problems); ornew or changing breast lumps. Other, less serious side effects may be more likely to occur. Continue to use estradiol and norethindrone and talk to your doctor if you experiencenausea and vomiting; tenderness or enlargement of the breasts; weakness; swelling of the hands or feet; spotty darkening of the skin, particularly on the face; difficulty in wearing contact lenses; vaginal irritation or discomfort; a rash or reaction at the patch application site; orchanges in menstrual cycle, painful menstruation, or breakthrough bleeding. Estradiol increases the risk of developing endometrial hyperplasia, a condition that may lead to cancer of the lining of the uterus. Using a progestin, such as norethindrone, with estradiol lowers the risk of developing this condition. Visit your doctor regularly and report any unusual vaginal bleeding right away. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1- 8. FDA- 1. 08. 8. See also: Side effects (in more detail)Estradiol and norethindrone Dosing Information. Usual Adult Dose for Atrophic Urethritis: One (1 mg estradiol/0. One (0. 0. 5 mg- 0. You may not be able to use estradiol and norethindrone, or you may require a dosage adjustment or special monitoring during treatment if you are taking warfarin (Coumadin). Drugs other than those listed here may also interact with estradiol and norethindrone. Talk to your doctor and pharmacist before taking any prescription or over- the- counter medicines, including herbal products. Where can I get more information? Your pharmacist has additional information about estradiol and norethindrone written for health professionals that you may read. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
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